PC-6 Acupressure: A Science-Backed Solution for Stress and Anxiety Relief
Feeling Overwhelmed? Your Wrist Holds the Key to Calm
In the midst of tight deadlines, back-to-back meetings, and constant digital overload, stress can feel like an unavoidable part of your day. But what if a simple pressure point on your wrist could provide immediate relief?
The Pericardium 6 (PC-6) acupressure point, located on the inner wrist, has been scientifically proven to reduce stress, anxiety, and even physiological responses to emotional distress. Research shows that stimulating PC-6 can help regulate the nervous system, lower cortisol levels, and restore a sense of calm—without requiring medication or disrupting your workflow.
If you’re struggling with workplace stress, anxiety, or even tension-induced nausea, keep reading to discover how PC-6 can be your go-to acupressure trick for instant relaxation.
What Is PC-6 and How Does It Work?
PC-6, also known as Neiguan, is a pressure point located three finger-widths below the wrist crease, between the two central tendons. It is commonly used in Traditional Chinese Medicine (TCM) to calm the mind, relieve nausea, and regulate heart function.
But beyond traditional practices, modern neuroscience confirms that PC-6 has a direct impact on brain activity, stress response, and emotional regulation.
How PC-6 Impacts the Brain and Nervous System
Recent research using functional magnetic resonance imaging (fMRI) has revealed that stimulating PC-6 alters activity in key brain regions associated with stress and anxiety (PMC Study). According to the study, acupressure on PC-6:
- Increases activation in the left parahippocampal gyrus, an area linked to emotional processing
- Decreases activity in the right middle frontal gyrus, which is associated with overthinking and anxiety
- Modulates the autonomic nervous system, helping shift the body from “fight or flight” to a more relaxed state
This means that applying pressure to PC-6 can physically change how your brain responds to stress, promoting relaxation and emotional stability.
PC-6 as a Natural Stress and Anxiety Relief Technique
Many professionals experience stress not just mentally but physically—tight shoulders, headaches, digestive issues, and even increased heart rate. Studies have shown that PC-6 can effectively target these symptoms.
A study published in the Journal of Anesthesia and Surgery found that acupressure on PC-6 significantly reduced preoperative anxiety in patients (SCIRP Study). This suggests that PC-6 isn’t just useful for mild stress—it can even help in high-pressure situations like surgery prep.
Another study in Evidence-Based Complementary and Alternative Medicine found that PC-6 stimulation reduces stress-related behaviors by calming activity in the amygdala, the brain’s fear center (Wiley Study). This means activating PC-6 can reduce emotional reactivity and help you stay composed in stressful situations.
How to Use PC-6 for Instant Stress Relief
You don’t need any special tools—just your fingers and 30 seconds. Here’s how to stimulate PC-6 effectively:
- Locate the Point:
- Turn your palm facing up.
- Measure three finger-widths down from your wrist crease.
- Feel for the two central tendons—PC-6 is between them.

- Apply Firm Pressure:
- Use your opposite thumb to press firmly on PC-6.
- Hold for 30–60 seconds while taking slow, deep breaths.
- Repeat on the other wrist if needed.
- Use It During Stressful Moments:
- Before an important meeting or presentation to stay calm
- During a stressful conversation to prevent emotional overwhelm
- Before bed to ease tension and promote better sleep
Beyond Stress: Other Benefits of PC-6
PC-6 isn’t just for stress—it’s a multi-purpose acupressure point with additional benefits:
- Reduces motion sickness and nausea (widely used for chemotherapy patients)
- Eases heart palpitations and improves cardiovascular function
- Relieves wrist pain caused by prolonged typing and repetitive strain
- Helps regulate emotions and manage fear responses (Frontiers Study)
Final Thoughts: Your 30-Second Stress Solution
If you’re constantly battling stress, anxiety, or work-induced tension, PC-6 is a scientifically-backed, drug-free way to regain control. Instead of relying on caffeine or endless scrolling to cope, try 30 seconds of PC-6 acupressure.
It’s quick, effective, and always accessible—right on your wrist.
Give it a try the next time you feel overwhelmed, and see how this simple yet powerful technique can transform your stress response.
Want to integrate more stress-relief techniques into your workday? Let me know, and I can share a quick 5-minute acupressure routine to keep you feeling balanced and focused!

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